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Picking an Open-Source Agent Framework: LangGraph, CrewAI, and AutoGen

· 11 min read
Suresh Thomas
Founder, JigsawFlux

The first decision in any agentic project isn't which model to use. It's which framework will orchestrate it. Get that wrong and you inherit a stack you can't run locally, can't afford to scale, and can't escape when the vendor changes the API.

This is a JigsawFlux project. JigsawFlux builds open-source tools for health tech, humanitarian response, and crisis management — in places where "cloud-native" is not an option and IT budgets are measured in grants, not headcount. That context imposes hard constraints on every architecture decision: portability, cost, and freedom from vendor lock-in.

The frameworks here — LangGraph, CrewAI, and AutoGen — were chosen because they meet those constraints. They are open source, actively maintained, and run entirely on hardware you own. Alternatives like Microsoft Semantic Kernel or Amazon Bedrock Agents are capable, but they introduce hard dependencies on specific cloud ecosystems. That trade-off doesn't fit the JigsawFlux model.

Agent Clinic: Human-in-the-Loop Medical Consultations with LangGraph and AWS Bedrock

· 17 min read
Suresh Thomas
Founder, JigsawFlux

The name cuts two ways. It's a clinic — for patients. And the clinic runs on agents.

The problem this POC targets is specific: small and charity hospitals where doctor time is genuinely scarce and IT budgets are measured in hundreds of dollars, not thousands. A consultation isn't just a diagnosis — it's intake, medical history retrieval, triage sorting, prescription recording, pharmacy stock checking. The typical workflow hands all of that to a doctor anyway, because there's no other option. The result: a clinician spending 40% of their time on work that doesn't require clinical judgment.

The premise here is simple. AI handles everything that doesn't require a clinician. The doctor steps in exactly once — to read the AI-produced intake summary and give a diagnosis. That's it. The prescription agent takes over from there.

This is a JigsawFlux project. JigsawFlux builds open-source tools for health tech, things that matters — tools that have to work in the real world, not the well-funded one. That means two hard constraints shaped every architecture decision here: cost and deployability. Viable on a shoestring budget. Runnable in places where "cloud-native" isn't an option — a clinic with a single server, unreliable internet, and an IT team of one.

Built on AWS Bedrock (Claude Haiku 4.5), LangGraph for orchestration, LangChain @tool wrappers for data access, and Streamlit for the UI. Total cost: < $0.01 per consultation. Deployable on a £25/month VPS or a clinic's own hardware, with the option to go fully on-premises as models improve.